Indien

Seit vielen Jahren arbeiten Frau Prof. Dr. Regine Schneider-Stock und Frau Prof. Dr. Vijayalakshmi Mahadevan vom Institute of Bioinformatics and Applied Biotechnology (IBAB) wissenschaftlich zusammen. Frau Prof. Schneider-Stock betreute von 2008 bis 2013 zwei indische PhD-Studenten, die 2013 ihre Doktorarbeiten abgeschlossen haben.

Forschungsschwerpunkte:

• Systembiologie von Progressionsmarkern in Tumoren
• Epigenetische Marker in entzündungsassoziierten Tumore

Gemeinsame Publikationen:

1. Huebner K, Erlenbach-Wuensch K, Prochazka J, Sheraj I, Hampel C, Mrazkova B, Michalcikova T, Tureckova J, Iatsiuk V, Weissmann A, Ferrazzi F, Kunze P, Nalli E, Sammer E, Gehring A, Cheema MM, Eckstein M, Paap EM, Soederberg A, Fischer C, Paul S, Mahadevan V, Ndreshkjana B, Meier MA, Muehlich S, Geppert CI, Merkel S, Grutzmann R, Roehe A, Banerjee S, Hartmann A, Sedlacek R, Schneider-Stock R. ATF2 loss promotes tumor invasion in colorectal cancer cells via upregulation of cancer driver TROP2. Cell Mol Life Sci. 2022 Jul 15;79(8):423.
2. Lindner P, Paul S, Eckstein M, Muenzner JK, Erlenbach-Wünsch K, Ahmed HP, Mahadevan V, Brabletz T, Hartmann A, Vera J, Schneider-Stock R. EMT transcription factor ZEB1 alters the epigenetic landscape of colorectal cancer cells. Cell Death Dis. 2020; 11:147
3. Huebner K, Procházka J, Monteiro AC, Mahadevan V, Schneider-Stock R. The activating transcription factor 2: an influencer of cancer progression. Mutagenesis. 2019;34:375-389. Review  
4. Maiuthed A, Ninsontia C, Erlenbach-Wuensch K, Ndreshkjana B, Muenzner JK, Caliskan A, Husayn AP, Chaotham C, Hartmann A, Vial Roehe A, Mahadevan V, Chanvorachote P, Schneider-Stock R. Cytoplasmic p21 Mediates 5-Fluorouracil Resistance by Inhibiting Pro-Apoptotic Chk2. Cancers (Basel). 2018; 10  [IF  6,12]
5. Benderska N, Dittrich AL, Knaup S, Rau TT, Neufert C, Wach S, Fahlbusch FB, Rauh M, Wirtz RM, Agaimy A, Srinivasan S, Mahadevan V, Rümmele P, Rapti E, Gazouli M, Hartmann A, Schneider-Stock R. miRNA-26b Overexpression in Ulcerative Colitis-associated Carcinogenesis. Inflamm Bowel Dis. 2015; 21(9):2039-51.
6. lvanovska J, Mahadevan V, Schneider-Stock R. DAPK and cytoskeleton-associated functions. Apoptosis. 2014; 19(2):329-338 [IF: 3.6]
7. EI-Baba C, Mahadevan V, Fahlbusch FB, S SM, Rau TT, Gali-Muhtasib H, Schneider-Stock R. Thymoquinone-induced conformational changes of PAK1 interrupt prosurvival MEK-ERK signaling in colorectal cancer. Mol Cancer. 2014; 13(1):201
8. Benderska N, Ivanovska J, Rau TT, Schulze-Luehrmann J, Mohan S, Chakilam S, Gandesiri M, Ziesché E, Fischer T, Söder S, Agaimy A, Distel L, Sticht H, Mahadevan V, Schneider-Stock R. DAPK-HSF1 interaction as a positive-feedback mechanism stimulating TNF-induced apoptosis in colorectal cancer cells.J Cell Sci. 2014; 127(24):5273-87
9. Ivanovska J, Tregubova A, Mahadevan V, ChakilamS, Gandesiri M, Benderska N, Ettle B, Hartmann A, Söder S, Ziesché E, Fischer T, Lautscham L, Fabry B, Segerer G, Gohla A, Schneider-Stock R. Identification of DAPK as a scaffold protein for the LIMK/cofilin complex in TNF-induced apoptosis. Int J Biochem Cell Biol. 2013; 45(8): 1720-1729

Links:
https://www.ibab.ac.in/
https://www.ibab.ac.in/research/vijayalakshmi-mahadevan/